Allogeneic Hematopoietic Cell Transplantation (HCT) for Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Allogeneic hematopoietic cell transplantation for infants with acute lymphoblastic leukemia.

The role of transplantation in infants with acute lymphoblastic leukemia (ALL) is not defined. We analyzed results of 40 infants diagnosed before age 12 months who received a hematopoietic cell transplant (HCT) between July 1982 and February 2003 in first complete remission (CR1; n = 17), CR2/3 (n = 7), or relapse (n = 16). Patients were conditioned with cyclophosphamide with total body irradia...

Hematopathology / ADULT T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

We analyzed the clinicopathologic and molecular findings in 26 adults (age 16-72 years) with T-cell acute lymphoblastic leukemia (T-ALL) and observed features that correlated with age. Patients older than 60 years (n = 5) had a low frequency of hepatosplenomegaly (0 [0%]), anterior mediastinal mass (1 [20%]), and lymphadenopathy (2 [40%]), and completely responded to chemotherapy (4 of 4). The ...

[Hematopoietic stem cell transplantation for adult acute lymphoblastic leukemia].

allogeneic stem cell transplantation outcome in acute lymphoblastic leukemia patients

introduction: despite achievement to complete remission (cr) with current treatments and new multiple chemotherapeutic agents in acute lymphoblastic leukemia (all) patients, the majority of them still relapse during long-term follow-up. the use of post- remission therapy will reduce early relapse in these cases, but the best option is still debatable. patients and methods: in this retrospective...

allogeneic hematopoietic stem cell transplantation for adult acute lymphoblastic leukemia: results from a single center, 1993-2011

background: for adult all patients, the indications and appropriate timing of allogeneic hematopoietic stem cell transplantation (ahsct) continue to be debated. the primary aim of this single-institution study was to compare the results of our adult all patients that had been allografted with those reported in the current literature. subjects and methods: this study included 53 consecutive adul...